Table 4.
Cox Multivariable Analysis of Overall Survival in All Primary Malignant Peripheral Nerve Sheath Tumors: Radiation Sequence and Extent of Surgery
| Characteristic | Definition | Multivariable Analysis | Multivariable Analysis | ||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | ||
| Age | 19-59 | Ref. | Ref. | ||||
| <18 | 0.79 | 0.66-0.97 | .020 | 0.80 | 0.66-0.97 | .023 | |
| 60+ | 1.79 | 1.60-1.99 | <.001 | 1.78 | 1.59-1.98 | <.001 | |
| Sex | Female | Ref. | Ref. | ||||
| Male | 1.15 | 1.04-1.27 | .008 | 1.16 | 1.05-1.28 | .005 | |
| Race | White | Ref. | Ref. | ||||
| Black | 1.27 | 1.09-1.46 | .002 | 1.23 | 1.06-1.42 | .006 | |
| Asian and other | 0.93 | 0.77-1.12 | .432 | 0.93 | 0.77-1.12 | .431 | |
| Unknown | 0.42 | 0.14-1.32 | .137 | 0.40 | 0.13-1.26 | .117 | |
| Therapy | Sx only | ||||||
| Rx only | |||||||
| Sx and Rx | |||||||
| None | |||||||
| Unknown | |||||||
| Surgery | GTR | Ref. | |||||
| PR | 1.10 | 0.96-1.27 | .174 | ||||
| Biopsy | 1.56 | 1.13-2.14 | .007 | ||||
| No Sx | 1.93 | 1.60-2.32 | <.001 | ||||
| Sx NOS | 1.16 | 1.00-1.35 | .055 | ||||
| Unknown | 1.97 | 1.53-2.52 | <.001 | ||||
| Radiation Sequence | No Sx or no Rx | Ref. | |||||
| Rx after Sx | 0.97 | 0.86-1.09 | .569 | ||||
| Rx before Sx | 0.85 | 0.67-1.09 | .209 | ||||
| Rx b/a Sx | 0.74 | 0.40-1.39 | .355 | ||||
| Rx intraop | 0.72 | 0.32-1.60 | .418 | ||||
| Unknown | 0.98 | 0.44-2.19 | .958 | ||||
| Tumor Location | Limbs | Ref. | Ref. | ||||
| Intracranial | 0.88 | 0.66-1.17 | .380 | 0.74 | 0.55-1.00 | .046 | |
| Spinal | 1.23 | 0.91-1.66 | .177 | 1.31 | 0.97-1.77 | .084 | |
| H&N | 1.32 | 1.11-1.58 | .002 | 1.28 | 1.08-1.53 | .005 | |
| Core | 1.62 | 1.44-1.83 | <.001 | 1.57 | 1.39-1.77 | <.001 | |
| NOS and Unknown | 1.99 | 1.61-2.45 | <.001 | 1.73 | 1.40-2.15 | <.001 | |
| Tumor Grade | I | Ref. | Ref. | ||||
| II | 1.33 | 0.94-1.88 | .113 | 1.35 | 0.96-1.92 | .101 | |
| III | 2.83 | 2.02-3.96 | <.001 | 2.82 | 2.02-3.95 | <.001 | |
| IV | 3.40 | 2.45-4.71 | <.001 | 3.40 | 2.45-4.71 | <.001 | |
| Unknown | 2.44 | 1.79-3.34 | <.001 | 2.32 | 2.32-1.69 | <.001 | |
| Tumor Size | ≤50 mm | Ref. | Ref. | ||||
| >50 mm | 2.33 | 2.00-2.72 | <.001 | 2.33 | 1.99-2.72 | <.001 | |
| Unknown | 1.93 | 1.65-2.25 | <.001 | 1.82 | 1.55-2.13 | <.001 | |
Abbreviations: b/a, before and after; CI, confidence interval; GTR, gross total resection; H&N, head and neck; HR, hazard ratio; intraop, intraoperatively; NOS, not otherwise specified; PR, partial resection; Ref., reference; Rx, radiotherapy; Sx, surgery.