Table 5.
Neonatal outcome according to gestational age at amniocentesis
| Characteristics | −25.9 weeks (n=16)a |
26–33.9 weeks (n=37)b |
34–36.9 weeks (n=15) |
P-value |
|---|---|---|---|---|
| Birth weight | 742 ± 430 | 1645 ± 513 | 2441 ± 303 | <.001 |
| Apgar score at 1 min <7 | 100% (16/16) | 64.9% (24/37) | 20.0% (3/15) | <.001 |
| Apgar score at 5 min <7 | 81.3% (13/16) | 16.2% (6/37) | 0% (0/15) | <.001 |
| Neonatal death | 37.5% (6/16) | 13.5% (5/37) | 0% (0/15) | .015 |
| Significant morbidityc | 91.7% (11/12) | 62.2% (23/37) | 26.7% (4/15) | .003 |
| Respiratory distress syndrome | 41.7% (5/12) | 18.9% (7/37) | 0% (0/15) | .022 |
| Bronchopulmonary dysplasia | 72.7% (8/11) | 18.8% (6/32) | 0% (0/15) | <.001 |
| Intraventricular hemorrhage | 25.0% (3/12) | 32.4% (12/37) | 14.3% (2/14) | .422 |
| Necrotizing enterocolitis | 25.0% (3/12) | 2.7% (1/37) | 0% (0/15) | .011 |
| Proven early neonatal sepsis | 8.3% (1/12) | 0% (0/37) | 6.7% (1/15) | .236 |
a
One case with unavailable data were excluded from analysis
b
Two cases with unavailable data were excluded from analysis
c
Four neonates who died in utero or immediately after birth because of extreme prematurity and thus could not be evaluated with respect to the presence or absence of complications were excluded from the analysis.