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. Author manuscript; available in PMC: 2019 Jul 24.
Published in final edited form as: ACS Chem Neurosci. 2017 Dec 27;9(1):11–28. doi: 10.1021/acschemneuro.7b00388

Figure 5.

Figure 5.

(a) Schematic illustrating the design of a dual-targeted gold nanoparticle (AuNP) system used to target glioblastoma (GBM) cells. The particles are functionalized with multiple receptor binding peptides to address intratumoral heterogeneity of GBM populations and the photosentizer phthalocyanine 4. (b) Transmission electron microscope image of hydrophobic gold nanoparticles used to prepare dual-targeted AuNPs. Scale bar = 100 nm. (c) Schematic illustrating nanoparticle targeting of U-251 glioblastoma cells. Localization of the gadolinium-tagged nanoparticles to glioblastoma cells implanted into mouse models is monitored via magnetic resonance imaging. Panels (a) and (b) reprinted with permission from ref 10. Copyright 2015 American Chemical Society. Panel (c) reprinted with permission from ref 162. Copyright 2015 American Chemical Society.