Table 3.
IPA Core Pathway of Highly Predicted Targets of miR-130b-3p That Include DENND1A.V2, LHCGR, RAB5B, and MAPK1 Signaling Pathways
| Top Networks | ||
|---|---|---|
| Score | ||
| Endocrine system development and function, lipid metabolism, small molecule biochemistry | 21 | |
| Organ development, cellular growth and proliferation, organ morphology and development | 7 | |
| Top Canonical Pathways | ||
| P Value | Overlap, % | |
| Gs signaling | 1.17E-05 | 2.8 |
| Ovarian cancer signaling | 3.59E-05 | 1.9 |
| cAMP-mediated signaling | 1.09E-04 | 1.3 |
| G-Protein-coupled receptor signaling | 1.94E-03 | 0.7 |
| Caveolar-mediated endocytosis signaling/synaptogenesis signaling pathway | 2.48E-03 | 0.6 |
| Top Diseases and Bio-Functions | ||
| P Value | Molecules | |
| Endocrine system disorders | 1.29E-02–9.26E-06 | 7 |
| Organism injury/abnormalities | 4.97E-02–2.67E-06 | 9 |
| Reproductive system disease | 4.87E-02–2.67E-06 | 7 |
| Cancer | 4.87E-02–2.67E-06 | 9 |
| Tumor morphology | 4.48E-02–2.67E-06 | 3 |
| Physiological System Development and Function | ||
| P Value | Molecules | |
| Embryonic development | 8.04E-03–4.48E-04 | 3 |
| Organ development | 2.48E-02–4.48E-04 | 3 |
| Organismal development | 1.56E-02–4.48E-04 | 4 |
| Endocrine system development and function | 1.51E-02–3.21E-06 | 4 |
| Organ morphology | 2.00E-02–4.48E-04 | 3 |
Key findings from Core Pathway Analysis (performed in IPA) of the predicted interactions of miR-130b-3p with the three PCOS GWAS candidates (DENND1A.V2, LHCGR, RAB5B), as well as the signaling component MAPK1.