Table 7.
GDM-Induced Enrichment of Inflammatory Response Genes in 15-Wk-Old Offspring Islets
| Gene Symbol | Gene Name | GDM-LF | GDM-HFS |
|---|---|---|---|
| Birc3 | Baculoviral IAP repeat containing 3 | 1.9 | 0.7 |
| Cfb | Complement factor B | 2.0 | −0.4 |
| Cldn2 | Claudin 2 | 3.8 | 0.5 |
| Csf3 | Colony stimulating factor 3 | 4.5 | 2.0 |
| Cxcl6 | C-X-C motif chemokine ligand 6 | 3.7 | 1.7 |
| Fga | Fibrinogen alpha chain | 1.8 | 2.0 |
| Gabrp | Gamma-aminobutyric acid type A receptor pi subunit | 3.8 | 0.6 |
| Grin1 | Glutamate ionotropic receptor NMDA type subunit 1 | −1.7 | −1.4 |
| Hpx | Hemopexin | 1.6 | 0.5 |
| Ifit3 | Interferon induced protein with tetratricopeptide repeats 3 | 3.3 | 1.0 |
| Il1a | Interleukin 1 alpha | 5.3 | 2.1 |
| Il1b | Interleukin 1 beta | 3.5 | 1.2 |
| Il1rl1 | Interleukin 1 receptor like 1 | 2.8 | 1.7 |
| Il11 | Interleukin 11 | 1.5 | 0.8 |
| Irf7 | Interferon regulatory factor 7 | 2.5 | 0.6 |
| Isg15 | ISG15 ubiquitin-like modifier | 3.2 | 1.6 |
| Lcn2 | Lipocalin 2 | 2.0 | −0.5 |
| Mmp9 | Matrix metallopeptidase 9 | 3.1 | 0.7 |
| Mx2 | MX dynamin like GTPase 1 | 3.2 | 1.1 |
| Ngf | Nerve growth factor | 1.8 | 0.3 |
| Oas1a | 2′-5′-Oligoadenylate synthetase 1 | 3.1 | 1.3 |
| Ptges | Prostaglandin E synthase | 2.8 | 1.1 |
| Ptgs2 | Prostaglandin-endoperoxide synthase 2 | 2.0 | −0.2 |
| Ptx3 | Pentraxin 3 | 2.8 | −1.6 |
| Sod2 | Superoxide dismutase 2 | 1.5 | 0.6 |
Data are log2 fold change. Fold cutoff (−1.5-fold or fewer changes or 1.5-fold or more changes), FDR of ≤0.05.