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. 2019 Apr 24;24(7):989–996. doi: 10.1634/theoncologist.2019-0047

Figure 1.

image

MDM2 copy number alterations in MDM2‐amplified DDLPS. Distribution of MDM2 copy number status from 642 patients with DDLPS provided by FMI. MDM2 copy number demonstrated a right‐skewed distribution (A) and best fit a log‐normal distribution as corroborated by the overlap between the empirical and theoretical CDF (B). Distribution of MDM2 copy number status from 57 patients with DDLPS as part of TCGA sarcoma data set. MDM2 copy number demonstrated a right‐skewed distribution (C) and best fit a log‐normal distribution as corroborated by the overlap between the empirical and theoretical CDF (D). (E): MDM2 copy numbers from two independent data sets, FMI and TCGA, followed a similar distribution demonstrating a Hellinger distance of 0.14.

Abbreviations: CDF, cumulative distribution function; FMI, Foundation Medicine Inc.; MDM2, murine double minute 2; TCGA, The Cancer Genome Atlas.