Fig. 3. Thermoresponsiveness of AAD and in vitro contraction on skin.

(A) Thermoresponsive behavior varies with the matrix composition of HN. 1%A and 5%A refer to 1% and 5% of acrylamide within the total monomer. SN represents PNIPAm-only gel used as a control. (B) Areal strains as a function of the matrix composition measured under equilibrium conditions at 37°C. Negative values of the areal strain indicate contraction, whereas positive values indicate expansion. Mean ± SD, n = 3 to 4. (C) In vitro tests of AAD-enabled wound contraction on fresh rodent skin. Comparison of the wound area between nontreatment control, nonthermoresponsive dressing TA, and AAD. Mean ± SD, n = 5, ****P < 0.0005. Photo credit: Jianyu Li and David Mooney, Harvard University.