Fig. 6. Wound closure rate, as characterized by the time for 50% wound closure (t_1/2) with various reported wound dressings.

Comparisons include AAD (data reported in Fig. 4), microgels (25), chitosan (35), dopamine-modified polyacrylamide (PAAm-Dopa) (50), gelatin (51), alginate-gelatin hydrogels (52), carbon nanotube–laden chitosan hydrogels (chitosan-CNT) (53), polycaprolactone nanofibrous matrix (PCL) (54), hyaluronan (HA), and chondroitin sulfate (CS) hydrogels (55). The half-life time (t_1/2) resulting from chondroitin sulfate hydrogels was beyond 20 days. While AAD and microgels were tested in a rodent wound model with splints, most previous reports did not use splinting.