TABLE 1.

Parameters for Time to Recovery

Definition of time to recovery (TTR)*

1st day meeting organ failure recovery criteria in all systems listed below, without any subsequent days with further organ system failure

Cardiovascular recovery

Mean arterial pressure >60 mm Hg and no inotropic/vasopressor support (dopamine, dobutamine, epinephrine, norepinephrine, phenylephrine, or vasopressin)

Hematologic recovery

Platelet count >120,000/μL

Hepatic recovery

Serum bilirubin <3 mg/dL

Renal recovery

No dialysis and creatinine <1.3 mg/dL

Respiratory recovery

No mechanical ventilation or PaO2/FiO2 >300

Organ injury was derived from a composite of the Denver and Marshall MOF Scores, adding hematologic recovery to the Denver score, and removing the Glasgow Coma Scale (GCS) from the Marshall score. GCS is more subjective and clinician-dependent, and subjects with significant TBI were purposefully excluded from enrollment.

^*A surviving patient who did not recover by day 28 was assigned a TTR value of 29 days, whereas a patient who died prior to day 28 was assigned a TTR value of 30 days.