. Author manuscript; available in PMC: 2020 Jul 24.

Published before final editing as: Ann Surg. 2019 Jan 24:10.1097/SLA.0000000000003204. doi: 10.1097/SLA.0000000000003204

TABLE 4.

Area Under Receiver Operating Curve and Odds Ratios for Clinical Indices at 24 h, and Plasma IL-6 and s63 Levels at 12 and 24 h Dichotomizing Trauma Patients Based on Time to Recovery (TTR)

Outcome (TTR < 5 d vs ≥ 5 d)	12 h		24 h
Variable	AUC (95% CI)	Odds Ratio (95% CI)	AUC (95% CI)	Odds Ratio (95% CI)

APACHE II			0.71 (0.60–0.81)	1.121 (1.053–1.194)
ISS			0.77 (0.67–0.87)	1.092 (1.046–1.141)
IL-6	0.72 (0.62 0.83)	1.003 (1.001–1.006)	0.73 (0.64–0.83)	1.000 (1.000–1.001)
S63 Gene DFR	0.65 (0.54–0.76)	1.008 (1.002–1.015)	0.80 (0.70–0.89)	1.014 (1.007–1.021)
Adaptive immunity Gene DFR	0.62 (0.50–0.73)	1.013 (1.001–1.025)	0.77 (0.67–0.87)	1.027 (1.015–1.039)
Endothelial biology Gene DFR	0.64 (0.53–0.75)	1.056 (0.999–1.116)	0.74 (0.64–0.84)	1.086 (1.015–1.161)
Inflammatory responses Gene DFR	0.73 (0.63–0.82)	1.127 (1.038–1.223)	0.70 (0.61 −0.80)	1.140 (1.022–1.271)
S63 DFR + IL-6	0.75 (0.65–0.85)	IL-6 1.003 (1.000–1.005) S63 DFR 1.005 (0.998–1.012)	0.82 (0.73–0.90)	IL-6 1.000 (0.999–1.000) S63 DFR 1.020 (1.011–1.029)
S63 DFR + APACHE II + ISS			0.84 (0.76–0.92)	APACHE II 1.055 (0.981–1.134) ISS 1.062 (1.014–1.113) S63 DFR 1.009 (1.002–1.017)
S63 DFR + APACHE II + ISS + IL-6			0.86 (0.79–0.93)	APACHE II 1.060 (0.979–1.147) ISS 1.057 (1.007–1.110) IL-6 1.000 (0.999–1.000) S63 DFR 1.016 (1.006–1.025)

Outcome (TTR < 14 d vs ≥ 14 d)	12 h		24 h
Variable	AUC (95% CI)	Odds Ratio (95% CI)	AUC (95% CI)	Odds Ratio (95% CI)

APACHE II			0.66 (0.55–0.76)	1.094 (1.038–1.152)
ISS			0.57 (0.46–0.67)	1.017 (0.989–1.046)
IL-6	0.68 (0.57–0.78)	1.001 (1.000–1.002)	0.68 (0.58–0.78)	1.000 (1.000–1.001)
S63 Gene DFR	0.59 (0.48–0.70)	1.003 (1.000–1.006)	0.66 (0.56–0.76)	1.005 (1.001–1.008)
Adaptive immunity Gene DFR	0.53 (0.43–0.64)	1.002 (0.995–1.010)	0.67 (0.57–0.77)	1.012 (1.003–1.021)
Endothelial biology Gene DFR	0.58 (0.47–0.68)	1.011 (0.994–1.028)	0.65 (0.55–0.75)	1.033 (1.000–1.068)
Inflammatory responses Gene DFR	0.70 (0.60–0.80)	1.034 (1.008–1.061)	0.70 (0.61 −0.80)	1.053 (1.012–1.095)
S63 DFR + IL-6	0.68 (0.58–0.79)	IL-6 1.001 (1.000–1.002) S63 DFR 1.001 (0.998–1.005)	0.69 (0.59–0.79)	IL-6 1.000 (1.000–1.001) S63 DFR 1.005 (1.001–1.008)
S63 DFR + APACHE II + ISS			0.69 (0.59–0.79)	APACHE II 1.076 (1.016–1.140) ISS 0.996 (0.964–1.028) S63 DFR 1.003 (1.000–1.007)
S63 DFR + APACHE II + ISS + IL-6			0.69 (0.59–0.79)	APACHE II 1.061 (0.998–1.128) ISS 0.997 (0.964–1.030) IL-6 1.000 (1.000–1.001) S63 DFR 1.003 (1.000–1.007)