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. 2019 Jul 10;28:100901. doi: 10.1016/j.rmcr.2019.100901

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© 2019 Published by Elsevier Ltd.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 3 — (A) A suspected EGFR T790M variant (Ct = 36.96) was not scored within the therascreen^® reference range (upper panel). Alternatively, cancer hotspot NGS accurately called this variant at 5% allele fraction (lower panel). (B) Another example of a late EGFR T790M therascreen^® curve (Ct = 32.96) resulted in the deltaCt not within the reference range (upper panel). Cancer hotspot NGS identified this variant at 2% allele fraction (lower panel). Note: the EGFR exon 19 deletions are not shown in the NGS pileup results.