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. 2019 Jul 24;9:10742. doi: 10.1038/s41598-019-47195-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Examples of histology from a responder and a non-responder. (a) 1x magnification H&E slide of responder; (b) 1x magnification Ki-67 staining from responder (positive tissue shown in brown and negative tissue shown in blue); (c) 1x magnification H&E slide of non-responder; (d) 1x magnification Ki-67 staining from non-responder (positive tissue shown in brown and negative tissue shown in blue); (e) 20x magnification of Ki-67 staining in a HGSOC patient, with positive cells in dark brown and background counter staining in blue; (f) automated image segmentation in Halo for quantification of Ki-67 staining. Positive cells are shown in dark brown and negative cells are shown in blue. (g) Scatterplot of mean tissue K_app against percentage of cells positive for Ki-67 staining (optical density > 31). White circles indicate responders, black circles indicate non-responders and crosses indicate the two patients treated with primary surgery before starting adjuvant chemotherapy.