Table 1.

Structures and IC₅₀ values of KMO inhibitor compounds

Compounds 9, 11–13 and 16–19 are structurally similar to the KMO inhibitor 6-(3,4-dichlorophenyl) pyrimidine-4-carboxylic acid¹³, in which the pyrimidine ring of the reported inhibitor is replaced by an isosteric furan ring in 9, 11–13 and 16–19. Compound 8 has been described previously as an inhibitor of KMO³²