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. 2019 Jul 24;9:10765. doi: 10.1038/s41598-019-47262-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MRI coronal images of mice (a,d,g) before application, (b,e,h) 10 min and (c,f,i) 60 min after application of (a–c) Fe₃O₄@PEG-Ner-10, (d–f) Fe₃O₄@PEG-Ner-20, and (g–i) Fe₃O₄@PEG-Ner-31 particles. High nanoparticle concentration in the blood after administration was manifested by a strong hypointense signal in the veins, clearly visible in the kidneys. Note also strong hypointense signal of (b,c) Fe₃O₄@PEG-Ner-10 and (g,h) Fe₃O₄@PEG-Ner-31 in the liver caused by faster clearance via the liver and weak hypointense signal of (e,f) Fe₃O₄@PEG-Ner-20 in the liver caused probably by slower clearance and thus prolonged blood circulation time. Images were obtained by a gradient echo sequence with weak T₂* weighting.