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. 2019 Jul 24;9:10731. doi: 10.1038/s41598-019-46917-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Schistosome eggs induced dysregulation of apoptosis-related genes in H69 cells. Volcano plot of the H69 cell gene response to non-contact co-culture with S. mansoni or S. haematobium eggs as indicated for 24 hours. Gene expression was measured using qPCR gene arrays designed to assess apoptosis-associated transcripts. Significantly dysregulated (P < 0.05) genes with >±1.5-fold-change, are shown. (Table S1 includes the complete data set of gene expression changes.) Panel B. Venn diagram compiled only with the H69 cell culture conditions that share differentially expressed genes (DEG) – only downregulated genes were shared between the two conditions indicated.