Table 2.

Statistics of somatic mutations detected by whole exome sequencing of CRC tumours.

Patienta	Frameshift insertion	Frameshift deletion	Frameshift substitution	Stopgain	Stoploss	Nonframeshift insertion	Nonframeshift deletion	Nonframeshift substitution	Missense SNVb	Synonymous SNVb	Unknown	Total
P0123	27	129	0	51	2	0	4	0	869	389	1	1,472
P0825	125	422	0	56	3	5	35	0	1,181	494	2	2,323
P0909	114	190	0	46	3	0	3	0	1,440	582	0	2,378
P0413	27	156	0	60	0	1	11	0	929	427	3	1,614
P0215	5	22	0	9	1	6	14	0	79	42	0	178
P0411	2	6	0	6	0	1	2	0	68	29	0	114
P0701	2	3	0	11	0	2	0	0	102	46	0	166
P1012	4	11	0	10	0	0	2	0	180	63	0	270
P1207	2	5	0	3	0	1	7	0	59	36	0	113
P1212	6	5	0	4	0	2	3	0	135	52	0	207
P1228	3	7	0	7	0	0	1	0	88	46	0	152
P0309	0	1	0	2	0	0	0	0	40	15	0	58

Somatic mutations were detected by variant caller Strelka and were annotated with ANNOVAR.

^aMSI pateints are labelled in bold.

^bSNV,single nucleotide variant.