Table 1.
Top five up and down-regulated circRNAs in clone 1 vs. control based on FC.
| CircRNA | Genomic Location | Expression | Fold Change | p-value | Parental Gene | Gene Function |
|---|---|---|---|---|---|---|
| hsa_circ_0001275 | chr3:17059499-17059748 | up | 5.8 | 0.0473 | PLCL2 | Complimentary to Gleason score for the prognostic classification of patients PCa30 |
| hsa_circ_0026462 | chr12:53068519-53069224 | up | 5.7 | 0.0260 | KRT1 | Target receptor highly expressed on breast cancer cells41 |
| hsa_circ_0033144 | chr14:99723807-99724176 | up | 5.2 | 0.0128 | BCL11B | Methylated in PCa42 |
| hsa_circ_0000673 | chr16:11940357-11940700 | up | 4.2 | 0.0383 | RSL1D1 | Overexpression is associated with an aggressive phenotype and poor prognosis in patients with PCa43 |
| hsa_circ_0000129 | chr1:151145974-151149507 | up | 3.9 | 0.0385 | VPS72 | May have a role in regulating long-term hematopoietic stem cell activity44 |
| hsa_circ_0022392 | chr11:61630443-61631258 | down | 20.2 | 0.0003 | FADS2 | Polymorphisms in the FADS gene cluster may have an impact on the effect of ω3 and ω6 PUFA on PCa risk amongst different populations45 |
| hsa_circ_0022383 | chr11:61605249-61615756 | down | 15.9 | 0.0011 | ||
| hsa_circ_0022382 | chr11:61605249-61608197 | down | 14.6 | 0.0002 | ||
| hsa_circ_0000518 | chr14:20811404-20811554 | down | 16.2 | 0.0281 | RPPH1 | ncRNA involved in processing of tRNA precursors by cleaving the trailer sequence from the 5′-end46 |
| hsa_circ_0071174 | chr4:151656409-151729550 | down | 2.4 | 0.0031 | LRBA | LRBA has been implicated in regulating endosomal trafficking, particularly endocytosis of ligand-activated receptors47 |