Table 2.
Top five up and down-regulated circRNAs in clone 9 vs. control based on FC.
| CircRNA | Genomic Location | Expression | Fold Change | p-value | Parental Gene | Gene Function |
|---|---|---|---|---|---|---|
| hsa_circ_0045697 | chr17:73736438-73753899 | up | 4.7 | 0.0297 | ITGB4 | Involved in prostate tumorigenesis and cancer invasiveness32 |
| hsa_circ_0000463 | chr12:132609079-132609271 | up | 4.0 | 0.0088 | EP400NL | Pseudogene |
| hsa_circ_0026462 | chr12:53068519-53069224 | up | 3.5 | 0.0254 | KRT1 | Target receptor highly expressed on breast cancer cells41 |
| hsa_circ_0000673 | chr16:11940357-11940700 | up | 3.5 | 0.0054 | RSL1D1 | Overexpressed in PCa43 |
| hsa_circ_407059 | intronic | up | 3.2 | 0.0018 | FGFR1 | Role in prostate tumorigenesis (40) |
| hsa_circ_0000326 | chr11:65272490-65272586 | down | 6.4 | 0.0351 | XLOC_l2_002352 | Undefined |
| hsa_circ_0022383 | chr11:61605249-61615756 | down | 6.1 | 0.0244 | FADS2 | Polymorphisms in the FADS gene may have an impact on the effect of ω3 and ω6 PUFA on PCa risk among different populations45 |
| hsa_circ_0022392 | chr11:61630443-61631258 | down | 4.1 | 0.0298 | ||
| hsa_circ_0078607 | chr6:160819010-160831878 | down | 5.9 | 0.0113 | SLC22A3 | Contributes to PCa pathogenesis48 |
| hsa_circ_0002082 | chr11:65271199-65272066 | down | 5.8 | 0.0371 | MALAT1 | Plays a role in AR-V7 resistance49 |