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Age-related penetrance of the developement of MEN1 syndrome presumption (a) and the major manifestations: PHPT (b), PA (c), and GEP-NET (d) in MEN1-positive vs. MEN1-negative probands with the same manifestation. P-values marked with * mean significant associations. MEN1 multiple endocrine neoplasia type 1, PHPT primary hyperparathyroidism, PA pituitary adenoma, GEP-NET gastroenteropancreatic neuroendocrine tumor
