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. 2019 Jul 24;9:10749. doi: 10.1038/s41598-019-47186-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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General wellbeing parameters are reduced in osteotomy groups and influenced by anesthesia and analgesia. (a,b) Mice were transferred individually to observation boxes, allowed to acclimate for 1 min and were observed for 3 min. Facial expression and appearance composite score was assessed in the OT (a) and AN (b) groups at 1, 6, 12, 24, 48 and 72 h post-osteotomy/post-anesthesia. DW groups were continuously scored with 0. Measured scores are shown as scatter dot plot and bar with median ± interquartile range for n = 8 (OT) and n = 4 (AN). Wilcoxon signed rank test was used to determine statistical significance towards the initial score (hypothetical median = 0; exact p-values are listed in Supplementary Table S4); p-values are indicated with *p < 0.05, **p < 0.01 and ***p < 0.001. (c) Nest complexity score of the OT groups are depicted for 0, 6, 12, 24 and 48 h post-osteotomy. Data are shown as scatter dot plot and bar with median ± interquartile range for n = 4 (cages). (d) The explorative test score is depicted for the OT groups as mean – percentage of cages that were determined positive for n = 4 (cages). Nest complexity and explorative test scores are provided in Supplementary Fig. S2.