Skip to main content
. Author manuscript; available in PMC: 2019 Jul 25.
Published in final edited form as: Science. 2019 Mar 29;363(6434):eaat9691. doi: 10.1126/science.aat9691

Fig. 6. A model of Pf4-mediated inhibition of TNF and phagocytosis.

Fig. 6.

Bacterial ligands stimulate TNF production and phagocytosis in BMDCs. Pf4 gets taken up through endocytic pathways, where Pf RNA stimulates TLR3-mediated TRIF signaling, which induces IFN production. IFN inhibits TNF production and phagocytosis.