Table 1.
Expression Levels of Members of the miR-200 Family and ZEB1, ZEB2, or CDH1 in PDAC Tumors as Compared with Adjacent Normal Tissue
| miR-200a | miR-200b | miR-429 | miR-200c | miR-141 | miR-205 | ZEB1 | ZEB2 | CDH1 | |
|---|---|---|---|---|---|---|---|---|---|
| Overexpressiona | 14/31, 45% | 9/31, 29% | 19/31, 61% | 9/31, 29% | 8/31, 26% | 20/31, 65% | 13/31, 42% | 5/31, 16% | 2/31, 6.5% |
| Underexpressiona | 7/31, 23% | 4/31, 13% | 5/31, 16% | 12/31, 39% | 5/31, 16% | 6/31, 19% | 9/31, 29% | 9/31, 29% | 11/31, 35.5% |
| Unchangeda | 10/31, 32% | 18/31, 58% | 7/31, 23% | 10/31, 32% | 18/31, 58% | 5/31, 16% | 9/31, 29% | 17/31, 55% | 18/31, 58% |
| Ct values (range): normal tissue | 23–32 | 25–33 | 31–36 | 21–29 | 24–32 | 26–37 | 27–40 | 27–36 | 24–28 |
| Ct values (range): tumoral tissue | 22–30 | 25–30 | 30–34 | 21–26 | 23–29 | 26–37 | 27–40 | 27–35 | 24.3–28 |
Fold change (2−ΔΔCt) > 2: overexpression; fold change (2−ΔΔCt) < 0.5: underexpression.
a
The proportion of tumors overexpressing (FC > 2) and underexpressing (FC < 0.5) the target gene is shown as a percentage.