Table 4.

Growth and Dissemination Patterns of Pancreatic PDXs and Genetic Characterization of Xenograft Samples (Orthotopic and Corresponding Metastases)

	PDX TP1	PDX TP5	PDX TP7	PDX TP9	PDX TP10	PDX TP11	PDX TP16	PDX TP18	PDX TP19	PDX TP26	PDX TP32
Timea	4.5	2.5–3	3	2.5	1–1.5	2.75	4	8.5	2.5–3	2	8
Differentiationb	mod	mod	poor	poor	poor	poor	poor	poor	mod	poor	mod
Local invasion	yes	yes	yes	yes	yes	yes	yes	yes	yes	yes	yes
Metastasis
Peritoneal	×		×	×	×	×	×	×	×	×	×
Lymph node	×	×			×	×		×		×	×
Diaphragm	×	×			×			×
Lung	×
Liver						×
Genetic Alterations
KRAS	c.35G>A (p.G12D)	c.35G>A (p.G12D)	c.35G>C (p.G12R)	c.35G>A (p.G12D)	WT	c.35G>T (p.G12V)	c.35G>A (p.G12D)	WT	c.35G>A (p.G12D)	c.35G>A (p.G12D)	WT
BRAF	WT	WT	WT	WT	WT	WT	WT	WT	WT	WT	WT
PI3KCA	WT	WT	WT	WT	WT	WT	WT	WT	WT	WT	WT
EGFR	WT/del	amp	WT/amp	WT	del/amp	WT	WT	WT/amp	WT/amp	WT/del	WT
CDKN2A	c.330G>A (p.W110*)	WT	c.238C>T (p.R80*)	e1-3Del	WT	c.47-50del (p.L16P fs*9)	e1-3Del	e1-3Del	WT	e1-3Del	e1Del
TP53	c.725G>C (p.C242S)	c.214dup (p.V73Rfs*76)	c.818G>A (p.R273H)	c.818G>T (p.R273L)	c.727A>G (p.M246V)	c.214dup (p.V73R fs*76)	c.949del (p.Q317Sfs*28)	WT	WT	WT	c.526T>C (p.C176R)
SMAD4	WT	e1-11Del	WT	c.1052-1054del p.D351del	c.354G>A (p.A118 =)	WT	WT	WT	c.344G>A (p.C115Y)	WT	e8-11Del

amp, amplification; del, deletion; mod, moderate; WT, wild type.

^aTime elapsed between passages (months).

^bDissemination: no, absence; yes, presence.