FIGURE 1.

Schematic of the tumor tissue based model. The compartmental model describes the reaction network of four major angiogenic factors (VEGF, FGF2, TSP1, and PF4) in the extracellular space of tumor tissue. Angiogenic receptors are expressed on the cell surfaces. Soluble angiogenic factors exist in the interstitial space, and they bind to cell surface receptors to form signaling complexes. Two different heparan sulfate proteoglycans are included in the model, including cell surface HSPG (cHSPG) and interstitial HSPG (iHSPG).