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Visual predictive check of the cosine model. Solid lines are the 10th and 90th (blue) and 50th (red) percentiles of the observed data, and the shaded areas are the 95% confidence intervals around the corresponding percentiles of the predictions. Observed and simulated QTcF data were prediction corrected (predcorr) before plotting. FIH, first in human; h, hour; MAD, multiple‐ascending dose; SAD, single‐ascending dose.
