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. 2019 May 22;8(7):500–510. doi: 10.1002/psp4.12414

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© 2019 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of the American Society for Clinical Pharmacology and Therapeutics.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Average fold error of predicted to simulated median fluconazole plasma concentration in preterm and term infants. Average fold error of the predicted to observed plasma concentration is plotted against postmenstrual age (a) and serum creatinine (b) for each infant in the prophylaxis and PPRU studies following various treatment and prophylactic fluconazole dosing regimens. Symbol size is scaled according to the number of observed samples obtained from each infant. Dashed lines represent the twofold error range. Predicted concentration was obtained from a simulated population of 1,000 virtual infants for the prophylaxis study and populations of 100 virtual infants for each individual infant in the PPRU study. PPRU, Pediatric Pharmacology Research Unit.