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. 2019 May 22;8(7):500–510. doi: 10.1002/psp4.12414

Figure 5.

Figure 5

Comparison of PBPK model‐derived fluconazole clearance to clearance derived from a PopPK model and clearance reported by the product label. Circles represent the mean ratio of PBPK‐derived clearance to PopPK‐derived clearance estimates from a previous study.11, 18, 23 The model parameters from the PPRU study PopPK model were used to generate the PopPK‐derived individual empirical Bayesian clearance estimates. Triangles represent the mean ratio of PBPK‐derived clearance to clearance values reported by the fluconazole product label for infants 26–29 weeks gestational age.7 Tails represent ± 1 standard deviation ratio24 and the shaded region represents the twofold error range. Mean ratios were calculated as the mean predicted (PBPK) value divided by the mean observed (PopPK or product label) value, and standard deviation ratios were calculated using the method published by Zhou et al.24 The product label does not provide a clearance value for infants as young as 25 weeks postmenstrual age. PBPK, physiologically‐based pharmacokinetic; PopPK, population pharmacokinetic.