Figure 6.

Fluconazole simulations of treatment dosing (12 mg/kg/day i.v.  ± 25 mg/kg i.v. loading dose). Simulations (n = 500 virtual infants) of exposure, measured by fAUC, in preterm infants following fluconazole treatment dosing regimens over 2 weeks. Longer dashed lines represent exposure in plasma, and shorter dashed lines represent exposure in CSF. The bolded black line represents the target exposure associated with clinical efficacy. Gray lines represent exposure following dosing according to current Infectious Disease Society of America guidelines of 12 mg/kg/day i.v., and red lines represent exposure following dosing using these same guidelines plus a loading dose of 25 mg/kg i.v. All lines are the 10th percentile of simulated plasma or CSF exposure, such that 90% of simulated infants achieved this exposure or higher. A fraction unbound of 0.89 was assumed for both plasma and CSF. CSF, cerebrospinal fluid; i.v., intravenous; fAUC, area under the unbound concentration‐time curve for each dosing day; i.v., intravenous.