Figure 6.

Physiologically‐based pharmacokinetic simulations for 800 mg darunavir once daily boosted with 100 mg ritonavir once daily (a) and 100 mg ritonavir once daily (b). The dashed line and the shaded area are the mean and the 95% confidence interval for the prediction of all virtual individuals, respectively. The solid lines how the mean of each virtual trial (10 trials with 12 virtual subjects per trial have been simulated). The red markers show observed clinical data (a: refs. 58, 59, 60 b: refs. 59, 61, 62). Conc., concentration; h, hour.