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. 2019 Apr 2;8(7):444–459. doi: 10.1002/psp4.12399

Table 2.

Observed vs. predicted pharmacokinetic parameters

Pharmacokinetic parameter Cmax (ng/mL) Tmax (h) AUC (ng × h/mL) t 1/2 (h)
Observed Predicted Observed Predicted Observed Predicted Observed Predicted
Rivaroxaban 10 mg 153.7 ± 23.7 162.7 ± 26.9 3.0 ± 0.5 1.5 ± 0.1 1,000 ± 161 1,208 ± 268 5.7 ± 1.8 12.5 ± 3.3
Rivaroxaban 10 mg + Ritonavir 600 mg twice daily 238.0 ± 55.7 197.4 ± 32.6 4.0 ± 2.2 1.6 ± 0.2 2,529 ± 425 2,761 ± 875 6.9 ± 2.2 20.2 ± 4.7
Ratio 1.55 ± 0.43 1.21 ± 0.28 1.33 ± 0.77 1.09 ± 0.14 2.53 ± 0.59 2.29 ± 0.88 1.21 ± 0.53 1.62 ± 0.57
Rivaroxaban 10 mg + Darunavir/r 800/100 mg once daily NA 190.0 ± 31.2 NA 1.7 ± 0.2 NA 2,510 ± 685 NA 19.9 ± 5.2
Ratio NA 1.17 ± 0.27 NA 1.16 ± 0.15 NA 2.08 ± 0.73 NA 1.60 ± 0.60
Darunavir/r 800/100 mg once daily 6,803 ± 1,618 5,432 ± 1,929 3.6 ± 1.6 3.1 ± 0.5 75,780 ± 22,102 75,002 ± 56,887 14.4 ± 5.2 10.9 ± 5.7
Ritonavir 100 mg once daily 606 ± 281 531 ± 280 3.1 ± 2.0 1.8 ± 0.5 5,296 ± 4,664 5,470 ± 3,132 6.3 ± 1.5 5.4 ± 1.4

Data are presented as mean +/‐ standard deviation. Observed data are published in ref. 57 for rivaroxaban, refs. 58, 59, 60 for darunavir, and refs.59, 61 for ritonavir.

Cmax, maximal concentration; Tmax, timepoint of the maximal concentration; AUC, area under the curve; t1/2 = elimination half‐life; NA = not applicable.