Table 4.
Hematological parameters in rats treated orally with unadulterated Lime Essential oil at sub-acute (+SEM) (n = 10).
| Hematological Parameters | Determined Dosages (mg/kg BW) |
||||
|---|---|---|---|---|---|
| Normal control | Low(50) | Medium (100) | High (500) | cReference range | |
| RBCs (M/u) | 3.97+ 0.01 | 6.68+0.02*** | 6.95+0.01*** | 7.55+0.03*** | 4.3–6.46 |
| Hematocrit (%) | 33.80+0.06 | 38.70+0.06*** | 38.10+0.06*** | 39.80+0.12 *** | 39–47 |
| MCV (fL) | 85.30+0.06 | 57.90+0.26*** | 55.90+0.29*** | 52.70+0.12*** | 70–88 |
| Hemoglobin(g/dL) | 13.60+0.17 | 12.80+0.12 ns | 7.70+0.12*** | 13.30+0.06 ns | 12.3–17.5 |
| MCH (pg) | 34.20+0.12 | 19.30+0.12*** | 19.50 +0.06*** | 17.60+0.06*** | 25-31 |
| MCHC (g/dL) | 40.20+0.12 | 33.30+0.17*** | 34.8+0.06*** | 33.40+0.23*** | 32-39 |
| Platelet (105/μL) | 6.13+0.56 | 7.52+ 1.16*** | 6.32+1.16*** | 9.67+0.58*** | 8.00–9.00 |
| Lymphocytes (%) | 35.20+0.06 | 75.50+0.29*** | 66.00+0.29*** | 79.50+0.29*** | 63–93 |
| MID (%) | 15.90+0.12 | 2.70+ 0.06*** | 1.10+0.06*** | 0.80+0.03*** | 13.0-16.0 |
RBC = red blood cells, MCV = mean corpuscular volume, MCH = mean corpuscular hemoglobin, MCHC = mean corpuscular hemoglobin concentration, MID = multi-infarct dementia. Note: Significant difference between Control group and Experimental group: ns implies non-significant difference; (*) = P < 0.05, (**) = P=<0.01, and (***) = P<0.001 [65,66]c.