Table 3.
Longitudinal OCT results of MOG-IgG-seropositive patients and HCs
Longitudinal OCT data | HC | MOG-IgG-seropositive patients EyeON- | MOG-IgG-seropositive patients EyeON+ | HC vs MOG-IgG-seropositive patients (EyeON- and EyeON+) | EyeON- vs EyeON+ | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Absolute change to baseline | |||||||||||
N (eyes) = 56 | N (eyes) = 18 | N (eyes) = 20 | [B] | [95%CI] | [SE] | [p] | [B] | [95%CI] | [SE] | [p] | |
GCIP [mean (SD)] | 0.00 (0.01) | 0.00 (0.01) | 0.00 (0.05) | − 0.000 | − 0.004; 0.005 | 0.002 | 0.884 | − 0.006 | − 0.016; 0.003 | 0.005 | 0.214 |
pRNFL [mean (SD)] | − 0.61 (2.00) | − 4.5 (5.89) | − 1.60 (4.48) | − 1.645 |
− 2.819; − 0.471 |
0.599 | 0.009 | 0.168 | − 1.380; 1.717 | 0.790 | 0.832 |
INL [mean (SD)] | 0.00 (0.01) | 0.01 (0.02) | 0.00 (0.03) | 0.002 | −0.002; 0.005 | 0.002 | 0.312 | − 0.003 |
− 0.011; 0.004 |
0.004 | 0.381 |
MV [mean (SD)] | 0.00 (0.02) | − 0.01 (0.04) | − 0.01 (0.05) | − 0.008 | − 0.016; 0.0013 | 0.004 | 0.103 | 0.002 | − 0.013; 0.018 | 0.008 | 0.769 |
Abbreviations: 95%CI 95% confidence interval, B Estimate (beta-coefficient), GCIP combined ganglion cell and inner plexiform layer, HC healthy control, INL inner nuclear layer, EyeON- MOG-IgG-seropositive patients without a history of ON, EyeON+ MOG-IgG-seropositive patients with a history of ON, OCT optical coherence tomography, p p value, pRNFL peripapillary retinal nerve fiber layer, SD standard deviation, SE standard error, MV macular volume, vs versus, N number of eyes