Fig. 7.

Combination of Taxol and MCT1 inhibition effectively suppresses Taxol resistant tumor growth in vivo. a–c Comparison of tumor volumes in pre-established MCF7 Taxol resistant cells tumor xenografts under treatments with control, Taxol alone (10 mg/kg, i.p., 3 times/wk), Taxol plus SR13800 (10 mg/kg, i.p., 3 times/wk), or Taxol plus miR-124 mimic (5 µL of 50 µM, i.p., 3 times/wk). d MCT1 mRNA expressions in MCF7 Taxol resistant cells tumor xenograft treated with control, Taxol alone, Taxol plus SR13800 and Taxol plus miR-124 mimic. *p < 0.05; **p < 0.01