Table 3.
Significant KEGG pathway analysis
| Pathway name | Gene involved | p | FDR | Genes | |
|---|---|---|---|---|---|
| 22PF vs 22AL (up) | |||||
| Up | Metabolism of xenobiotics by cytochrome P450 | 2/53 | 0.0110 | 0.782 | CYP2E1//SULT2A1 |
| Bile secretion | 2/59 | 0.0136 | 0.782 | OCT1//SULT2A1 | |
| PPAR signaling pathway | 2/64 | 0.0158 | 0.782 | APOC3//PCK1 | |
| Down | Dilated cardiomyopathy | 5/41 | 0.0003 | 0.0483 | ACTC1//MLC2V//PLN//TNNI3//TPM3 |
| Phagosome | 6/134 | 0.0003 | 0.0483 | GP91-PHOX//SLA-5//SLA-DQA1//SLA-DRB1//THBS1//THBS3 | |
| Antigen processing and presentation | 4/63 | 0.0011 | 0.054 | CD8A//SLA-5//SLA-DQA1//SLA-DRB1 | |
| 35AL vs 22AL | |||||
| Up | Ribosome | 6/83 | 0.0008 | 0.13 | RPL10A//RPL11//RPL14//RPLP1//RPS17//RPS4 |
| p53 signaling pathway | 5/60 | 0.0011 | 0.13 | BID//CDKN1A//FAS//GADD45A//IGF1 | |
| Adipocytokine signaling pathway | 3/61 | 0.0468 | 1 | PCK1//POMC//PPARGC-1 | |
| Down | Arginine and proline metabolism | 11/47 | 3.09E-07 | 7.64E-05 | ACY1//ALDH2//ARG2//CKM//CKMT2//GATM//GLUD1//GLUL//GOT1//GOT2//P4HA1 |
| Glycolysis/gluconeogenesis | 9/51 | 4.38E-05 | 0.0024 | ACSS2//ALDH2//DLAT//DLD//GPI//PFKM//PGM1//PKM2//TPI1 | |
| PPAR signaling pathway | 10/64 | 4.92E-05 | 0.0024 | ACADL//ACADM//ACOX1//ACSL1//CD36//CPT1B//CYP27A1//FABP3//LPL//SCD | |
| Phagosome | 14/134 | 0.0002 | 0.0056 | ACTB//ACTB//ATP6V1D//ATP6V1G1//CD36//EEA1//ITGAV//ITGB1//M6PR//SLA-1//SLA-3//SLA-5//SLA-DQA1//SLA-DRB1 | |
| Endocytosis | 16/179 | 0.0003 | 0.0081 | ADRB2//CAV1//CAV2//CXCR4//EEA1//EGF//EPS15//FOLR2//MDM2//MET//SLA-1//SLA-3//SLA-5//TGFB2//USP8//WWP1 | |
| Citrate cycle (TCA cycle) | 6/29 | 0.0004 | 0.0081 | DLAT//DLD//FH//IDH2//IDH3A//SDHA | |
| Dilated cardiomyopathy | 10/81 | 0.0004 | 0.0081 | ACTB//ACTB//ACTC1//DES//ITGAV//ITGB1//LMNA//SGCA//TGFB2//TPM2 | |
| Fatty acid metabolism | 7/41 | 0.0004 | 0.0081 | ACADL//ACADM//ACOX1//ACSL1//ALDH2//CPT1B//LCTHIO | |
| Valine, leucine and isoleucine degradation | 7/44 | 0.0006 | 0.0117 | ACADM//ALDH2//BCKDHA//BCKDHB//DLD//LCTHIO//PCCB | |
| Pyruvate metabolism | 6/36 | 0.0012 | 0.0194 | ACSS2//ALDH2//DLAT//DLD//GLO1//PKM2 | |
| Leukocyte transendothelial migration | 10/103 | 0.0024 | 0.0354 | ACTB//ACTB//CDH5//CTNNB1//CXCL12//CXCR4//F11R//ITGB1//MAPK14//RAP1A | |
| 35AL vs 22PF (up) | |||||
| Up | Adipocytokine signaling pathway | 3/60 | 1.6E-06 | 0.0004 | PCK1//POMC//PPARGC-1 |
| Herpes simplex infection | 8/157 | 0.0002 | 0.0193 | CASP3//CCL5//OAS1//OAS2//PTPN11//SLA//SOCS3//STAT2 | |
| Toll-like receptor signaling pathway | 6/87 | 0.0002 | 0.0193 | CCL5//CD40//CXCL10//MAPK14//TICAM2//TLR1 | |
| Down | Glycolysis/gluconeogenesis | 7/51 | 1.97E-05 | 0.0049 | DLD//ENO3//GPI//PFKM//PGM1//PKM2//TPI1 |
| Citrate cycle (TCA cycle) | 5/29 | 0.0001 | 0.0131 | DLD//FH//IDH2//IDH3A//MDH2 | |
| Hypertrophic cardiomyopathy (HCM) | 7/76 | 0.0003 | 0.0166 | CACNA2D1//DES//ITGB1//LMNA//SGCA//TGFB3//TPM2 | |
| Starch and sucrose metabolism | 5/35 | 0.0003 | 0.0166 | AMY2//GPI//PGM1//PYGM//UGP2 | |
| Dilated cardiomyopathy | 7/81 | 0.0004 | 0.0194 | CACNA2D1//DES//ITGB1//LMNA//SGCA//TGFB3//TPM2 | |
| Arginine and proline metabolism | 5/47 | 0.0011 | 0.0381 | ACY1//CKM//GLUD1//GOT1//MAOB | |
| PPAR signaling pathway | 4/64 | 0.022 | 1.6496 | ACADM//ACSL1//APOC3//CYP27A1 | |