Table 2.
Primary endpoints assessed at low altitude (760 m)
| Low altitude rehabilitation group | High altitude rehabilitation group | Between group difference of changes from BL to 3 weeks | Between group difference of changes from BL to 3 months | |||||
|---|---|---|---|---|---|---|---|---|
| Baseline | End of rehabilitation (3 weeks) | Follow-up (3 months) | Baseline | End of rehabilitation (3 weeks) | Follow-up (3 months) | |||
| PEF-Var. | 19 (14;33) | 15 (8;23) | 15 (9;24) | 17 (12;32) | 6 (4;9)# | 8 (5;14)# | ||
| change | −7.4 (−13.9 to 0)* | −2.5 (-17.5 to 2.1) | −10.4 (−21.3 to −3.4)** | −8.9 (-10.3 to -2.8)** | − 5.8 (− 14 to 2) | − 5 (− 13.6 to 5.0) | ||
| ACQ | 2.7 (1.7;3.2) | 0.8 (0.4;1.6) | 1.4 (0.9;2.1) | 2.0 (1.6;3.0) | 0.9 (0.4;1.6) | 1.6 (0.9;3.0) | ||
| change | -1.4 (-2.2 to −0.9)*** | − 0.9 (− 1.3 to −0.3)** | −1.1 (−1.3 to − 0.7)*** | −0.2 (-0.9 to 0.4) | 0.3 (-0.4 to 1.1) | 0.4 (− 0.4 to 1.1) | ||
Note: Data are given as median (quartiles) and median difference (confidence interval)
Abbreviations: PEF-Var. Peak-flow variability, %, ACQ Asthma Control questionnaire. *: p < 0.05; **: p < 0.01; ***: p < 0.001 tested with Wilcoxon test for paired samples (baseline vs. 3 weeks follow up and baseline vs. 3 months follow up). #: p < 0.05 vs. low altitude group