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. 2019 Jul 24;19:192. doi: 10.1186/s12935-019-0914-y

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — CC-CAFs-derived condition medium promotes migration and adhesion of CRC cells through HGF/MET/AKT signal in colorectal cancer. a Tumor cells were cultured in CC-CAFs-CM for 12 h with or without anti-HGF antibody or c-MET inhibitor SU11274. Protein expression was determined by western blotting and representative results from one of the three independent experiments are presented. b Adhesion assay (top) and migration assay (bottom) in SW48 cells and LOVO with or without anti-HGF antibody or c-MET inhibitor SU11274 (magnification, ×200). The migrated cells and adhered cells was quantified (n = 9). Error bars represent mean ± s.d; *P < 0.05, ***P < 0.001, ****P < 0.0001; by one-way analysis of variance (ANOVA)