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. 2019 Aug;47(8):928–940. doi: 10.1124/dmd.119.086538

Fig. 5.

Fig. 5.

Two-way hierarchical clustering dendrogram of carbohydrate and glycan metabolism genes that were differentially regulated across treatment groups in liver of GF and CV mice following exposures to BDE-47 and BDE-99 (A). Gene expression was quantified using RNA-Seq as previously reported (Li et al., 2017) and can be accessed through NCBI Gene Expression Omnibus (GSE101650). Euclidian distance and complete linkage were used to generate the dendrogram. Red indicates higher standardized mean metabolite relative abundances and blue lower. Asterisks (*) represent statistically significant differences between corn oil-treated and PBDE-treated groups (FDR adjusted P value <0.05). Caret signs (^) represent statistically significant baseline differences between CV and GF mice. Network of differentially regulated carbohydrate (GCK) and glycan (ALG12) metabolism genes (circles) and the significantly altered carbohydrate metabolite mannose (square), which was quantified using LC-MS, in liver (B). Mouse orthologs for human genes are listed in mixed case. Pearson correlation of log2 abundances of mannose and Alg2 across treatment group means (C). Means and S.E. of Alg12 and mannose for each treatment group (D). Asterisks (*) represent statistically significant differences between corn oil-treated and PBDE-treated groups (FDR adjusted P value <0.05, Cuffdiff). Caret signs (^) represent statistically significant baseline differences between CV and GF mice.