Fig. 10.

Caffeine pharmacokinetics in hCYP1A1/1A2, Cyp1a KO, and HRN mice extrapolated to humans. Caffeine pharmacokinetics in hCYP1A1/1A2, Cyp1a KO, and HRN mice extrapolated to humans using the complex Dedrick plot approach (see Materials and Methods for details). The caffeine concentration time course in placebo- or fluvoxamine-treated healthy subjects (Culm-Merdek et al., 2005) was corrected for mean caffeine concentration in predose. Symbols are the corrected caffeine concentrations measured in human plasma or extrapolated from mouse whole blood. All data are expressed as mean values (n = 4 mice per treatment group; n = 7 healthy subjects per treatment group).