Fig. 11.
Effect of fraction metabolized on AUC ratios of “substrate drug.” Simulation of AUC ratios of a substrate drug with inhibitor to that without inhibitor as a function of inhibitor concentration for different contributions of the inhibited enzyme [fraction metabolized (fm)] to the substrate drug elimination. The enzyme contribution is expressed as part of total clearance. Horizontal lines separate areas with strong (AUC ratio >5-fold), moderate (2 < AUC ratio < 5), weak (1.25 < AUC ratio < 2), and “no effect” (AUC ratio <1.25-fold) inhibition.