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. 2019 Jul 19;47(8):907–918. doi: 10.1124/dmd.119.087718

Fig. 7.

Fig. 7.

EROD and MROD activities catalyzed by liver microsomes from vehicle-treated hCYP1A1/1A2 humanized mice in the presence or absence of quinidine. EROD (A) and MROD (B) with and without quinidine catalyzed by liver microsomes from vehicle-treated (corn oil) hCYP1A1/1A2 humanized mice. Symbols are the measured reaction rates, and the line is derived from nonlinear regression analysis of the MROD in the absence of quinidine using eq. 5 (for details see Data Analysis in the Supplemental Materials).