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. 2019 Jul 19;47(8):907–918. doi: 10.1124/dmd.119.087718

Fig. 8.

Fig. 8.

Microsomal stability and in vitro clearance of ramelteon and tacrine. Microsomal stability (A and B) and in vitro clearance (C and D) of human CYP1A2 substrates ramelteon (A and C) and tacrine (B and D) measured in liver microsomes from WT, Cyp1a KO, and hCYP1A1/1A2 mice and human donors (human liver microsomes). Symbols are the measured concentrations of the compounds. A no-NADPH control was also run. Lines are nonlinear regression analysis using the equation for double-exponential (tacrine with Cyp1a KO microsomes) or monoexponential (all other incubations) decay in the software package GraFit 7.0.3. (Erithacus, West Sussex, UK).