Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jun 24;10(6):222–233. doi: 10.5306/wjco.v10.i6.222

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

PMC Copyright notice

Inhibition of IL-1 R tI abrogates leptin induction of Notch in endometrial cancer cells. A, B: Representative results from Western Blot (WB) analysis of the effects of IL-1R tI antibodies on leptin-induced levels of Notch proteins (receptors: Notch1, Notch2, Notch3 and Notch4, and ligands: JAG1 and DLL4) in Ishikawa [A, type I endometrial cancer (EmCa)] and An3Ca cells (B, type II EmCa). Cells were cultured for 24h with leptin (0 and 1.2nM), leptin signaling inhibitor IONP-LPrA2 (IONP), and IL-1R tI antibodies (IL-1R tI Ab). Quantitative WB data (relative protein expression %) were calculated from densitometric analysis of bands with the NIH image program. The values were normalized to GAPDH as protein loading control. Data (mean ± SE) are representative of the results derived from a minimum of three independent experiments. ⁱP < 0.05 and ^jP < 0.01 vs basal (no leptin).