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. 2019 Jul 18;10:468. doi: 10.3389/fendo.2019.00468

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Copyright © 2019 McGonagle and Nucera.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hypothetical cell composition of a BRAF^WT/V600E papillary thyroid carcinoma (PTC) nodule. BRAF^WT/V600E positive malignant thyroid nodule with heterogeneous tumor cell clusters that might have the potential for metastasis (arrows) to the neck lymph nodes (LN) and lungs/pleura. Red circles: diploid PTC cells; aqua and yellow circles: PTC cells with aneuploidy.