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. 2019 Jul 20;12(10):1305–1313. doi: 10.1016/j.tranon.2019.05.016

Fig. 4.

Fig. 4

miR-1236 or miR-1287 reverses the effects induced by circ-UBE2D2 in BC cells. (A, B) CCK-8 assay in circ-UBE2D2–overexpressing (A)/knockdown (B) BT-474 and MDA-MB-231 cells transfected with miR-1236/miR-1287 mimics (A) or inhibitors (B). (C, D) Transwell migration/invasion assay in circ-UBE2D2–overexpressing (C)/knockdown (D) BT-474 and MDA-MB-231 cells transfected with miR-1236/miR-1287 mimics (C) or inhibitors (D). (E) Cell apoptosis assay with flow cytometry in circ-UBE2D2–overexpressing/knockdown BT-474 and MDA-MB-231 cells transfected with miR-1236/miR-1287 mimics or inhibitors. (F) The schematic diagram of circ-UBE2D2 as a molecular sponge of miR-1236 and miR-1287 to accelerate the progression of BC.