Figure 4.

PKC activation correlates with metastatic potential of DAN cells in vivo. A, B – Firefly luciferase expressing DAN cells were intravenously injected subcutaneously via the tail vein in p53–/– mice. From the second day, mice were injected with either DMSO (A) or 1 nM of Go6983 (B). Mice were imaged by in vivo luciferase imaging up to 4 weeks to detect tumor formation. C – After euthanasia, bones from DMSO (vehicle) treated and Go6983 treated mice were excised and imaged by bioluminescence imaging to detect metastatic lesions. The mean luminescence intensity of the region of interest (ROI) is shown

*P < 0.05.