Figure 1.

Effects of eNOS or iNOS inhibition on the renal functional protection by RPEC treatment. A – Blood urea nitrogen (BUN), B – measurement of creatinine clearance (CCr), C – fractional excretion of Na⁺ (FE_Na+), D – urinary N-acetyl-β-D-glucosaminidase (NAG) levels, E – neutrophil gelatinase-associated lipocalin (NGAL) expression at 24 h after reperfusion

IR – ischemia/reperfusion group, RPEC – remote pre-conditioning group, L-NAME – nonspecific NOS inhibition + RPEC, 1400W – specific iNOS inhibition + RPEC. Each column and bar represent the mean ± SEM (n = 7). *P < 0.05 compared with the sham group; ^#p < 0.05 compared with the IR group; ^$p < 0.05 compared with the RPEC group.