Figure 7.

Schematic diagram depicting the possible mechanisms through which MMP13 regulates BACE1 translation. PI3K signalling downstream of MMP13 promotes eIF4B phosphorylation, which in turn facilitates the 5′UTR-dependent BACE1 translation. Consequently, increased BACE1 protein levels enhance amyloid-β production and impair cognitive function. The inhibition of MMP13 by CL82198 results in reduced BACE1 and amyloid-β accumulation in the brain, which contributes to the improved learning and memory functions in APP/PS1 mice. AD = Alzheimer;s disease; WT = wild-type.