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. 2019 Jul 21;12(10):1314–1322. doi: 10.1016/j.tranon.2019.05.013

Figure 5.

Figure 5

JHU-083 improves survival of mice with medulloblastoma tumors. A. 1 hour after a single dose of 20 mg/kg JHU-083, DON levels are detectable in mouse brain at a range from 8–12 nmol/g. There was no difference in DON levels in the different brain regions. P = 0.42 by one-way ANOVA, n = 5 brains. Error bars indicate standard deviation. B. Twice weekly 20 mg/kg dosing of JHU-083 significantly extended the survival of athymic nude mice with D425MED tumors. Dashed red line = JHU-083 Solid purple line = vehicle. P = 0.006 comparing treated vs vehicle control as determined by Log-rank test. N = 5 animals per group. C. H and E image (200X) of D425MED tumor (left) adjacent to normal cerebellum (right), showing large cell histology associated with group 3 medulloblastoma. D. Twice weekly 20 mg/kg JHU-083 treatment significantly extend the survival of C57BL/6J mice with mCB DNp53 MYC tumors. Dashed red line = JHU-083. Solid purple line = vehicle. P = 0.0001 comparing treated vs vehicle control as determined by Log-rank test. N = 10 animals per group. E) H and E image (200X) of mCB DNp53 MYC tumor (left) adjacent to normal cerebellum (right).