Figure 2.

Difference in mutation rates between extrahepatic cholangiocarcinoma, intrahepatic cholangiocarcinoma, and gallbladder carcinoma. (A) Significant differences in a range of gene mutation rates between extrahepatic cholangiocarcinoma, intrahepatic cholangiocarcinoma, and gallbladder carcinoma. Relative gene mutational frequencies across subtypes of biliary tract cancer. Horizontal brackets indicate significant differences by Chi-squared tests (P<0.05); (B) rates of homologous recombination repair deficiency, receptor tyrosine kinase mutations, and other significant actionable mutations across tumor subtypes. IHCC, intrahepatic cholangiocarcinoma; EHCC, extrahepatic cholangiocarcinoma; GBC, gallbladder carcinoma; CISH, chromogenic in situ hybridization; FISH, fluorescent in situ hybridization; IHC, immunohistochemistry.