Table 3. Toxicities.
Variable | Cap (N=36), n [%] | 5-FU (N=32), n [%] | Total (N=68), n [%] | P value |
---|---|---|---|---|
Hematological toxicities (≥ grade 3) | ||||
Neutropenia | 5 [14] | 6 [19] | 11 [16] | 0.744 |
Anemia | 3 [8] | 2 [6] | 5 [7] | 0.557 |
Thrombocytopenia | 0 [0] | 1 [3] | 1 [1] | 0.471 |
Common non-hematological toxicities | ||||
Radiation dermatitis | 0.740 | |||
Grade 2 | 13 [36] | 11 [34] | 24 [35] | |
Grade 3 | 14 [39] | 15 [47] | 29 [43] | |
Anal pain | 0.159 | |||
Grade 2 | 28 [78] | 18 [56] | 46 [68] | |
Grade 3 | 3 [8] | 4 [13] | 7 [10] | |
Diarrhea | 0.556 | |||
Grade 2 | 12 [33] | 15 [47] | 27 [40] | |
Grade 3 | 6 [17] | 5 [16] | 11 [16] | |
Nausea | 0.236 | |||
Grade 2 | 9 [25] | 3 [9] | 12 [18] | |
Grade 3 | 2 [6] | 2 [6] | 4 [6] | |
Uncommon non-hematological toxicities (≥ grade 2) | ||||
Stomatitis | 2 [6] | 10 [31] | 12 [18] | 0.009 |
Skin/soft tissue infection | 3 [8] | 2 [6] | 5 [7] | 1.000 |
Cystitis | 8 [22] | 4 [13] | 12 [18] | 0.353 |
Proctitis | 4 [11] | 2 [6] | 6 [9] | 0.676 |
Deep vein thrombosis | 0 [0] | 4 [13] | 4 [6] | 0.044 |
Acute coronary syndrome | 2 [6] | 2 [6] | 4 [6] | 1.000 |
Hand and foot syndrome | 4 [11] | 5 [16] | 9 [13] | 0.725 |
Cap, capecitabine; 5-FU, 5 fluorouracil.